- Painful mouth ulcers (sores) that do not heal for more than a few weeks
- Swelling in the neck of unknown cause
- Spontaneous tooth loss or wounds that do not heal after tooth extraction
- Unexplained numbness and numbness of the tongue or lips
- White and red areas in the mouth or tongue that do not change their location (these areas may be precursors of cancer)
- Speech disorder of unknown cause
